Naked mole rat TRF1 safeguards glycolytic capacity and telomere replication under low oxygen

The naked mole rat (NMR), a long-lived and cancer-resistant rodent, is highly resistant to hypoxia. Here, using robust cellular models wherein the mouse telomeric protein TRF1 is substituted by NMR TRF1 or its mutant forms, we show that TRF1 supports maximal glycolytic capacity under low oxygen, sho...

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Detalles Bibliográficos
Autores principales: Augereau, Adeline, Mariotti, Marco, Pousse, Mélanie, Filipponi, Doria, Libert, Frédérick, Beck, Benjamin, Gorbunova, Vera, Gilson, Eric, Gladyshev, Vadim N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7895426/
https://www.ncbi.nlm.nih.gov/pubmed/33608273
http://dx.doi.org/10.1126/sciadv.abe0174

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7895426/
https://www.ncbi.nlm.nih.gov/pubmed/33608273
http://dx.doi.org/10.1126/sciadv.abe0174

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