Cargando…

Imaging the mechanisms of anti-CD20 therapy in vivo uncovers spatiotemporal bottlenecks in antibody-dependent phagocytosis

Anti-CD20 antibody (mAb) represents an effective strategy for the treatment of B cell malignancies, possibly involving complement activity, antibody-dependent cellular cytotoxicity and phagocytosis (ADP). While ADP by Kupffer cells deplete circulating tumors, mechanisms targeting non-circulating tum...

Descripción completa

Detalles Bibliográficos
Autores principales:	Grandjean, Capucine L., Garcia, Zacarias, Lemaître, Fabrice, Bréart, Béatrice, Bousso, Philippe
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2021
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7895428/ https://www.ncbi.nlm.nih.gov/pubmed/33608271 http://dx.doi.org/10.1126/sciadv.abd6167

Ejemplares similares

Intravital imaging reveals improved Kupffer cell-mediated phagocytosis as a mode of action of glycoengineered anti-CD20 antibodies
por: Grandjean, Capucine L., et al.
Publicado: (2016)

Optogenetic manipulation of calcium signals in single T cells in vivo
por: Bohineust, Armelle, et al.
Publicado: (2020)

Spatiotemporal dynamics of calcium signals during neutrophil cluster formation
por: Khazen, Roxana, et al.
Publicado: (2022)

Single-cell imaging of CAR T cell activity in vivo reveals extensive functional and anatomical heterogeneity
por: Cazaux, Marine, et al.
Publicado: (2019)

Tumor-intrinsic sensitivity to the pro-apoptotic effects of IFN-γ is a major determinant of CD4(+) CAR T-cell antitumor activity
por: Boulch, Morgane, et al.
Publicado: (2023)

CD4 T cells integrate signals delivered during successive DC encounters in vivo
por: Celli, Susanna, et al.
Publicado: (2005)

Termination of T cell priming relies on a phase of unresponsiveness promoting disengagement from APCs and T cell division
por: Bohineust, Armelle, et al.
Publicado: (2018)

Percolation of heterogeneous flows uncovers the bottlenecks of infrastructure networks
por: Hamedmoghadam, Homayoun, et al.
Publicado: (2021)

Spatiotemporal dynamics of traffic bottlenecks yields an early signal of heavy congestions
por: Duan, Jinxiao, et al.
Publicado: (2023)

Dual checkpoint blockade of CD47 and LILRB1 enhances CD20 antibody-dependent phagocytosis of lymphoma cells by macrophages
por: Zeller, Tobias, et al.
Publicado: (2022)

A mechanical bottleneck explains the variation in cup growth during FcγR phagocytosis
por: van Zon, Jeroen S, et al.
Publicado: (2009)

Inconspicuous Consumption: Uncovering the Molecular Pathways behind Phagocytosis
por: Inman, Mason
Publicado: (2006)

Integration of intermittent calcium signals in T cells revealed by temporally patterned optogenetics
por: Corre, Béatrice, et al.
Publicado: (2023)

CD47 blocking antibodies restore phagocytosis and prevent atherosclerosis
por: Kojima, Yoko, et al.
Publicado: (2016)

Spatiotemporal control of actomyosin contractility by MRCKβ signaling drives phagocytosis
por: Zihni, Ceniz, et al.
Publicado: (2022)

Uncovering Spatiotemporal Dynamics of the Corticothalamic Network during Seizures
por: Panchavati, Saarang, et al.
Publicado: (2023)

On the Difference between the Information Bottleneck and the Deep Information Bottleneck
por: Wieczorek, Aleksander, et al.
Publicado: (2020)

The HIV-1 transmission bottleneck
por: Kariuki, Samuel Mundia, et al.
Publicado: (2017)

Antibody:CD47 ratio regulates macrophage phagocytosis through competitive receptor phosphorylation
por: Suter, Emily C., et al.
Publicado: (2021)

Identification of bottlenecks in antibody expression using targeted gene integration
por: Mayrhofer, Patrick, et al.
Publicado: (2015)

The Bottlenecks of Preparing Virus Particles by Size Exclusion for Antibody Generation
por: Lee, Chi-Hsin, et al.
Publicado: (2022)

Out of the bottleneck
por: Charpak, Georges
Publicado: (2004)

The Business Bottleneck
por: Cote, Michael
Publicado: (2020)

Influenza-Specific Antibody-Dependent Phagocytosis
por: Ana-Sosa-Batiz, Fernanda, et al.
Publicado: (2016)

PHAGOCYTOSIS OF BACTERIA IN THE ABSENCE OF ANTIBODY AND THE EFFECT OF PHYSICAL SURFACE : A REINVESTIGATION OF "SURFACE PHAGOCYTOSIS"
por: Lerner, Edwin M.
Publicado: (1956)

Monoclonal antibodies targeting CD20
por: Chang, Chien-Hsing, et al.
Publicado: (2013)

Lineage relationships, homeostasis, and recall capacities of central– and effector–memory CD8 T cells in vivo
por: Bouneaud, Cécile, et al.
Publicado: (2005)

Increased TCR signal strength in DN thymocytes promotes development of gut TCRαβ((+))CD8αα((+)) intraepithelial lymphocytes
por: Grandjean, Capucine L., et al.
Publicado: (2017)

Inflation as an Information Bottleneck
por: Westphal, Alexander
Publicado: (2019)

The Conditional Entropy Bottleneck
por: Fischer, Ian
Publicado: (2020)

Learnability for the Information Bottleneck
por: Wu, Tailin, et al.
Publicado: (2019)

Nonlinear Information Bottleneck
por: Kolchinsky, Artemy, et al.
Publicado: (2019)

On Bottlenecks, Helmholtz and Hearing
por: Ashmore, Jonathan F
Publicado: (2021)

Uncovering Spatiotemporal Characteristics of Human Online Behaviors during Extreme Events
por: Gao, Chao, et al.
Publicado: (2015)

Wine aging: a bottleneck story
por: Karbowiak, Thomas, et al.
Publicado: (2019)

Repression of phagocytosis by human CD33 is not conserved with mouse CD33
por: Bhattacherjee, Abhishek, et al.
Publicado: (2019)

Influenza A virus undergoes compartmentalized replication in vivo dominated by stochastic bottlenecks
por: Amato, Katherine A., et al.
Publicado: (2022)

Response to: Monoclonal antibodies targeting CD20
por: Klein, Christian, et al.
Publicado: (2013)

Dock2 generates characteristic spatiotemporal patterns of Rac activity to regulate neutrophil polarisation, migration and phagocytosis
por: Machin, Polly A., et al.
Publicado: (2023)

Uncovering the Cyclic AMP Signaling Pathway of the Protozoan Parasite Entamoeba histolytica and Understanding Its Role in Phagocytosis
por: Agarwal, Shalini, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_g9fisbltrppnkjhbjkbqnsq2j1