Patient-tailored design for selective co-inhibition of leukemic cell subpopulations

The extensive drug resistance requires rational approaches to design personalized combinatorial treatments that exploit patient-specific therapeutic vulnerabilities to selectively target disease-driving cell subpopulations. To solve the combinatorial explosion challenge, we implemented an effective...

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Detalles Bibliográficos
Autores principales: Ianevski, Aleksandr, Lahtela, Jenni, Javarappa, Komal K., Sergeev, Philipp, Ghimire, Bishwa R., Gautam, Prson, Vähä-Koskela, Markus, Turunen, Laura, Linnavirta, Nora, Kuusanmäki, Heikki, Kontro, Mika, Porkka, Kimmo, Heckman, Caroline A., Mattila, Pirkko, Wennerberg, Krister, Giri, Anil K., Aittokallio, Tero
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7895436/
https://www.ncbi.nlm.nih.gov/pubmed/33608276
http://dx.doi.org/10.1126/sciadv.abe4038

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7895436/
https://www.ncbi.nlm.nih.gov/pubmed/33608276
http://dx.doi.org/10.1126/sciadv.abe4038

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