Myosin with hypertrophic cardiac mutation R712L has a decreased working stroke which is rescued by omecamtiv mecarbil

Hypertrophic cardiomyopathies (HCMs) are the leading cause of acute cardiac failure in young individuals. Over 300 mutations throughout β-cardiac myosin, including in the motor domain, are associated with HCM. A β-cardiac myosin motor mutation (R712L) leads to a severe form of HCM. Actin-gliding mot...

Descripción completa

Detalles Bibliográficos
Autores principales: Snoberger, Aaron, Barua, Bipasha, Atherton, Jennifer L, Shuman, Henry, Forgacs, Eva, Goldman, Yale E, Winkelmann, Donald A, Ostap, E Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7895523/
https://www.ncbi.nlm.nih.gov/pubmed/33605878
http://dx.doi.org/10.7554/eLife.63691

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7895523/
https://www.ncbi.nlm.nih.gov/pubmed/33605878
http://dx.doi.org/10.7554/eLife.63691

Ejemplares similares