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Loss of cortical control over the descending pain modulatory system determines the development of the neuropathic pain state in rats

The loss of descending inhibitory control is thought critical to the development of chronic pain but what causes this loss in function is not well understood. We have investigated the dynamic contribution of prelimbic cortical neuronal projections to the periaqueductal grey (PrL-P) to the developmen...

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Detalles Bibliográficos
Autores principales: Drake, Robert AR, Steel, Kenneth A, Apps, Richard, Lumb, Bridget M, Pickering, Anthony E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7895525/
https://www.ncbi.nlm.nih.gov/pubmed/33555256
http://dx.doi.org/10.7554/eLife.65156