Poly(l-glutamic acid)-cisplatin nanoformulations with detachable PEGylation for prolonged circulation half-life and enhanced cell internalization

PEGylation has been widely applied to prolong the circulation times of nanomedicines via the steric shielding effect, which consequently improves the intratumoral accumulation. However, cell uptake of PEGylated nanoformulations is always blocked by the steric repulsion of PEG, which limits their the...

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Detalles Bibliográficos
Autores principales: Jiang, Zhongyu, Feng, Xiangru, Zou, Haoyang, Xu, Weiguo, Zhuang, Xiuli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: KeAi Publishing 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7895728/
https://www.ncbi.nlm.nih.gov/pubmed/33665501
http://dx.doi.org/10.1016/j.bioactmat.2021.01.034

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7895728/
https://www.ncbi.nlm.nih.gov/pubmed/33665501
http://dx.doi.org/10.1016/j.bioactmat.2021.01.034

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