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A data-driven computational model enables integrative and mechanistic characterization of dynamic macrophage polarization
Macrophages are highly plastic immune cells that dynamically integrate microenvironmental signals to shape their own functional phenotypes, a process known as polarization. Here we develop a large-scale mechanistic computational model that for the first time enables a systems-level characterization,...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7895754/ https://www.ncbi.nlm.nih.gov/pubmed/33659877 http://dx.doi.org/10.1016/j.isci.2021.102112 |