KPC-2 β-lactamase enables carbapenem antibiotic resistance through fast deacylation of the covalent intermediate

Serine active-site β-lactamases hydrolyze β-lactam antibiotics through the formation of a covalent acyl-enzyme intermediate followed by deacylation via an activated water molecule. Carbapenem antibiotics are poorly hydrolyzed by most β-lactamases owing to slow hydrolysis of the acyl-enzyme intermedi...

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Detalles Bibliográficos
Autores principales: Mehta, Shrenik C., Furey, Ian M., Pemberton, Orville A., Boragine, David M., Chen, Yu, Palzkill, Timothy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7895804/
https://www.ncbi.nlm.nih.gov/pubmed/33273017
http://dx.doi.org/10.1074/jbc.RA120.015050

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7895804/
https://www.ncbi.nlm.nih.gov/pubmed/33273017
http://dx.doi.org/10.1074/jbc.RA120.015050

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