Smac-mimetics reduce numbers and viability of human osteoclasts

Elevated activity of bone-degrading osteoclasts (OC) contributes to pathological bone degradation in diseases such as multiple myeloma. Several proinflammatory cytokines, including TNF, contribute to osteoclastogenesis. The receptor-interacting protein kinase 1 (RIPK1) regulates inflammation and cel...

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Detalles Bibliográficos
Autores principales: Moen, Ingrid Nyhus, Westhrin, Marita, Håland, Erling, Haug, Markus, Nonstad, Unni, Klaharn, Merisa, Standal, Therese, Starheim, Kristian K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7895921/
https://www.ncbi.nlm.nih.gov/pubmed/33608503
http://dx.doi.org/10.1038/s41420-021-00415-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7895921/
https://www.ncbi.nlm.nih.gov/pubmed/33608503
http://dx.doi.org/10.1038/s41420-021-00415-1

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