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Smac-mimetics reduce numbers and viability of human osteoclasts

Elevated activity of bone-degrading osteoclasts (OC) contributes to pathological bone degradation in diseases such as multiple myeloma. Several proinflammatory cytokines, including TNF, contribute to osteoclastogenesis. The receptor-interacting protein kinase 1 (RIPK1) regulates inflammation and cel...

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Detalles Bibliográficos
Autores principales:	Moen, Ingrid Nyhus, Westhrin, Marita, Håland, Erling, Haug, Markus, Nonstad, Unni, Klaharn, Merisa, Standal, Therese, Starheim, Kristian K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7895921/ https://www.ncbi.nlm.nih.gov/pubmed/33608503 http://dx.doi.org/10.1038/s41420-021-00415-1

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