Mitochondrial DNA editing in mice with DddA-TALE fusion deaminases

DddA-derived cytosine base editors (DdCBEs), composed of the split interbacterial toxin DddA(tox), transcription activator-like effector (TALE), and uracil glycosylase inhibitor (UGI), enable targeted C-to-T base conversions in mitochondrial DNA (mtDNA). Here, we demonstrate highly efficient mtDNA e...

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Detalles Bibliográficos
Autores principales: Lee, Hyunji, Lee, Seonghyun, Baek, Gayoung, Kim, Annie, Kang, Beum-Chang, Seo, Huiyun, Kim, Jin-Soo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7895935/
https://www.ncbi.nlm.nih.gov/pubmed/33608520
http://dx.doi.org/10.1038/s41467-021-21464-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7895935/
https://www.ncbi.nlm.nih.gov/pubmed/33608520
http://dx.doi.org/10.1038/s41467-021-21464-1

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