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3D spheroid models of paediatric SHH medulloblastoma mimic tumour biology, drug response and metastatic dissemination
Studying medulloblastoma, the most common malignant paediatric brain tumour, requires simple yet realistic in vitro models. In this study, we optimised a robust, reliable, three-dimensional (3D) culture method for medulloblastoma able to recapitulate the spatial conformation, cell–cell and cell–matr...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7895940/ https://www.ncbi.nlm.nih.gov/pubmed/33608621 http://dx.doi.org/10.1038/s41598-021-83809-6 |