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Positive feedback of SuFu negating protein 1 on Hedgehog signaling promotes colorectal tumor growth
Hedgehog (Hh) signaling plays a critical role in embryogenesis and tissue homeostasis, and its deregulation has been associated with tumor growth. The tumor suppressor SuFu inhibits Hh signaling by preventing the nuclear translocation of Gli and suppressing cell proliferation. Regulation of SuFu act...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7896051/ https://www.ncbi.nlm.nih.gov/pubmed/33608498 http://dx.doi.org/10.1038/s41419-021-03487-0 |