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Positive feedback of SuFu negating protein 1 on Hedgehog signaling promotes colorectal tumor growth

Hedgehog (Hh) signaling plays a critical role in embryogenesis and tissue homeostasis, and its deregulation has been associated with tumor growth. The tumor suppressor SuFu inhibits Hh signaling by preventing the nuclear translocation of Gli and suppressing cell proliferation. Regulation of SuFu act...

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Detalles Bibliográficos
Autores principales:	Yan, Zhengwei, Cheng, Minzhang, Hu, Guohui, Wang, Yao, Zeng, Shaopeng, Huang, Aidi, Xu, Linlin, Liu, Yuan, Shi, Chao, Deng, Libin, Lu, Quqin, Rao, Hai, Lu, Hua, Chen, Ye-Guang, Luo, Shiwen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7896051/ https://www.ncbi.nlm.nih.gov/pubmed/33608498 http://dx.doi.org/10.1038/s41419-021-03487-0

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