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Quercetin 3,5,7,3′,4′-pentamethyl ether from Kaempferia parviflora directly and effectively activates human SIRT1

Sirtuin 1 (SIRT1), an NAD(+)-dependent deacetylase, is a crucial regulator that produces multiple physiological benefits, such as the prevention of cancer and age-related diseases. SIRT1 is activated by sirtuin-activating compounds (STACs). Here, we report that quercetin 3,5,7,3′,4′-pentamethyl ethe...

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Detalles Bibliográficos
Autores principales: Zhang, Mimin, Lu, Peng, Terada, Tohru, Sui, Miaomiao, Furuta, Haruka, Iida, Kilico, Katayama, Yukie, Lu, Yi, Okamoto, Ken, Suzuki, Michio, Asakura, Tomiko, Shimizu, Kentaro, Hakuno, Fumihiko, Takahashi, Shin-Ichiro, Shimada, Norimoto, Yang, Jinwei, Ishikawa, Tsutomu, Tatsuzaki, Jin, Nagata, Koji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7896056/
https://www.ncbi.nlm.nih.gov/pubmed/33608631
http://dx.doi.org/10.1038/s42003-021-01705-1