Neuronal fragile X mental retardation protein activates glial insulin receptor mediated PDF-Tri neuron developmental clearance

Glia engulf and phagocytose neurons during neural circuit developmental remodeling. Disrupting this pruning process contributes to Fragile X syndrome (FXS), a leading cause of intellectual disability and autism spectrum disorder in mammals. Utilizing a Drosophila FXS model central brain circuit, we...

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Detalles Bibliográficos
Autores principales: Vita, Dominic J., Meier, Cole J., Broadie, Kendal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7896095/
https://www.ncbi.nlm.nih.gov/pubmed/33608547
http://dx.doi.org/10.1038/s41467-021-21429-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7896095/
https://www.ncbi.nlm.nih.gov/pubmed/33608547
http://dx.doi.org/10.1038/s41467-021-21429-4

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