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Selective ablation of type 3 adenylyl cyclase in somatostatin-positive interneurons produces anxiety- and depression-like behaviors in mice

BACKGROUND: Major depressive disorder (MDD) is a highly disabling psychiatric syndrome associated with deficits of specific subpopulations of cortical GABAergic interneurons; however, the underlying molecular mechanism remains unknown. Type 3 adenylyl cyclase (ADCY3, AC3), which is important for neu...

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Detalles Bibliográficos
Autores principales: Yang, Xiao-Yu, Ma, Zhao-Liang, Storm, Daniel R, Cao, Hong, Zhang, Yu-Qiu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7896247/
https://www.ncbi.nlm.nih.gov/pubmed/33643860
http://dx.doi.org/10.5498/wjp.v11.i2.35