Tau induces PSD95-nNOS uncoupling and neurovascular dysfunction independent of neurodegeneration

Cerebrovascular abnormalities have emerged as a preclinical manifestation of Alzheimer’s disease and frontotemporal dementia, diseases characterized by accumulation of hyperphosphorylated forms of the microtubule associated protein tau. However, it is unclear if tau contributes to these neurovascula...

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Detalles Bibliográficos
Autores principales: Park, Laibaik, Hochrainer, Karin, Hattori, Yorito, Ahn, Sung Ji, Anfray, Antoine, Wang, Gang, Uekawa, Ken, Seo, James, Palfini, Victoria, Blanco, Ismary, Acosta, Diana, Eliezer, David, Zhou, Ping, Anrather, Josef, Iadecola, Costantino
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7896353/
https://www.ncbi.nlm.nih.gov/pubmed/32778793
http://dx.doi.org/10.1038/s41593-020-0686-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7896353/
https://www.ncbi.nlm.nih.gov/pubmed/32778793
http://dx.doi.org/10.1038/s41593-020-0686-7

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