TREX2 Exonuclease Causes Spontaneous Mutations and Stress-Induced Replication Fork Defects in Cells Expressing RAD51(K133A)

DNA damage tolerance (DDT) and homologous recombination (HR) stabilize replication forks (RFs). RAD18/UBC13/three prime repair exonuclease 2 (TREX2)-mediated proliferating cell nuclear antigen (PCNA) ubiquitination is central to DDT, an error-prone lesion bypass pathway. RAD51 is the recombinase for...

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Detalles Bibliográficos
Autores principales: Ko, Jun Ho, Son, Mi Young, Zhou, Qing, Molnarova, Lucia, Song, Lambert, Mlcouskova, Jarmila, Jekabsons, Atis, Montagna, Cristina, Krejci, Lumir, Hasty, Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7896812/
https://www.ncbi.nlm.nih.gov/pubmed/33357432
http://dx.doi.org/10.1016/j.celrep.2020.108543

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7896812/
https://www.ncbi.nlm.nih.gov/pubmed/33357432
http://dx.doi.org/10.1016/j.celrep.2020.108543

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