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TREX2 Exonuclease Causes Spontaneous Mutations and Stress-Induced Replication Fork Defects in Cells Expressing RAD51(K133A)

DNA damage tolerance (DDT) and homologous recombination (HR) stabilize replication forks (RFs). RAD18/UBC13/three prime repair exonuclease 2 (TREX2)-mediated proliferating cell nuclear antigen (PCNA) ubiquitination is central to DDT, an error-prone lesion bypass pathway. RAD51 is the recombinase for...

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Detalles Bibliográficos
Autores principales:	Ko, Jun Ho, Son, Mi Young, Zhou, Qing, Molnarova, Lucia, Song, Lambert, Mlcouskova, Jarmila, Jekabsons, Atis, Montagna, Cristina, Krejci, Lumir, Hasty, Paul
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7896812/ https://www.ncbi.nlm.nih.gov/pubmed/33357432 http://dx.doi.org/10.1016/j.celrep.2020.108543

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