Cargando…
Structural insights into the substrate specificity of the endonuclease activity of the influenza virus cap-snatching mechanism
The endonuclease activity within the influenza virus cap-snatching process is a proven therapeutic target. The anti-influenza drug baloxavir is highly effective, but is associated with resistance mutations that threaten its clinical efficacy. The endonuclease resides within the N-terminal domain of...
| Autores principales: | , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2021
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7897473/ https://www.ncbi.nlm.nih.gov/pubmed/33469660 http://dx.doi.org/10.1093/nar/gkaa1294 |