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Structural insights into the substrate specificity of the endonuclease activity of the influenza virus cap-snatching mechanism

The endonuclease activity within the influenza virus cap-snatching process is a proven therapeutic target. The anti-influenza drug baloxavir is highly effective, but is associated with resistance mutations that threaten its clinical efficacy. The endonuclease resides within the N-terminal domain of...

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Detalles Bibliográficos
Autores principales:	Kumar, Gyanendra, Cuypers, Maxime, Webby, Richard R, Webb, Thomas R, White, Stephen W
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2021
Materias:	Nucleic Acid Enzymes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7897473/ https://www.ncbi.nlm.nih.gov/pubmed/33469660 http://dx.doi.org/10.1093/nar/gkaa1294

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