Super-enhancer mediated regulation of adult β-globin gene expression: the role of eRNA and Integrator

Super-enhancers (SEs) mediate high transcription levels of target genes. Previous studies have shown that SEs recruit transcription complexes and generate enhancer RNAs (eRNAs). We characterized transcription at the human and murine β-globin locus control region (LCR) SE. We found that the human LCR...

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Detalles Bibliográficos
Autores principales: Gurumurthy, Aishwarya, Yu, David T, Stees, Jared R, Chamales, Pamela, Gavrilova, Ekaterina, Wassel, Paul, Li, Lu, Stribling, Daniel, Chen, Jinyang, Brackett, Marissa, Ishov, Alexander M, Xie, Mingyi, Bungert, Jörg
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7897481/
https://www.ncbi.nlm.nih.gov/pubmed/33476375
http://dx.doi.org/10.1093/nar/gkab002

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7897481/
https://www.ncbi.nlm.nih.gov/pubmed/33476375
http://dx.doi.org/10.1093/nar/gkab002

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