A DYRK1B-dependent pathway suppresses rDNA transcription in response to DNA damage

DNA double-strand breaks (DSBs) at ribosomal gene loci trigger inhibition of ribosomal DNA (rDNA) transcription and extensive nucleolar reorganization, including the formation of nucleolar caps where rDNA DSBs engage with canonical DSB signaling and repair factors. While these nucleolar responses un...

Descripción completa

Detalles Bibliográficos
Autores principales: Dong, Chao, An, Liwei, Yu, Cheng-han, Huen, Michael S Y
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7897492/
https://www.ncbi.nlm.nih.gov/pubmed/33469661
http://dx.doi.org/10.1093/nar/gkaa1290

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7897492/
https://www.ncbi.nlm.nih.gov/pubmed/33469661
http://dx.doi.org/10.1093/nar/gkaa1290

Ejemplares similares