Cargando…

A DYRK1B-dependent pathway suppresses rDNA transcription in response to DNA damage

DNA double-strand breaks (DSBs) at ribosomal gene loci trigger inhibition of ribosomal DNA (rDNA) transcription and extensive nucleolar reorganization, including the formation of nucleolar caps where rDNA DSBs engage with canonical DSB signaling and repair factors. While these nucleolar responses un...

Descripción completa

Detalles Bibliográficos
Autores principales:	Dong, Chao, An, Liwei, Yu, Cheng-han, Huen, Michael S Y
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2021
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7897492/ https://www.ncbi.nlm.nih.gov/pubmed/33469661 http://dx.doi.org/10.1093/nar/gkaa1290

Ejemplares similares

Rapamycin increases rDNA stability by enhancing association of Sir2 with rDNA in Saccharomyces cerevisiae
por: Ha, Cheol Woong, et al.
Publicado: (2011)

Zebularine induces enzymatic DNA–protein crosslinks in 45S rDNA heterochromatin of Arabidopsis nuclei
por: Prochazkova, Klara, et al.
Publicado: (2021)

RNAi and Ino80 complex control rate limiting translocation step that moves rDNA to eroding telomeres
por: Apte, Manasi S, et al.
Publicado: (2021)

The β-1,3-glucanosyltransferase Gas1 regulates Sir2-mediated rDNA stability in Saccharomyces cerevisiae
por: Ha, Cheol Woong, et al.
Publicado: (2014)

More than 10% of yeast genes are related to genome stability and influence cellular senescence via rDNA maintenance
por: Saka, Kimiko, et al.
Publicado: (2016)

PARP-2 domain requirements for DNA damage-dependent activation and localization to sites of DNA damage
por: Riccio, Amanda A., et al.
Publicado: (2016)

An E2F7-dependent transcriptional program modulates DNA damage repair and genomic stability
por: Mitxelena, Jone, et al.
Publicado: (2018)

Nucleolar residence of the seckel syndrome protein TRAIP is coupled to ribosomal DNA transcription
por: Chen, Yangzi, et al.
Publicado: (2018)

DNA damage-induced inhibition of rRNA synthesis by DNA-PK and PARP-1
por: Calkins, Anne S., et al.
Publicado: (2013)

Susceptibility to bystander DNA damage is influenced by replication and transcriptional activity
por: Dickey, Jennifer S., et al.
Publicado: (2012)

MORC2 regulates DNA damage response through a PARP1-dependent pathway
por: Zhang, Lin, et al.
Publicado: (2019)

Polymerase η suppresses telomere defects induced by DNA damaging agents
por: Pope-Varsalona, Hannah, et al.
Publicado: (2014)

The transcription-coupled DNA repair-initiating protein CSB promotes XRCC1 recruitment to oxidative DNA damage
por: Menoni, Hervé, et al.
Publicado: (2018)

Regulation of nuclear DNA damage response by mitochondrial morphofunctional pathway
por: Oanh, Nguyen Thi Kim, et al.
Publicado: (2022)

XPD-dependent activation of apoptosis in response to triplex-induced DNA damage
por: Kaushik Tiwari, Meetu, et al.
Publicado: (2013)

Poly(ADP-ribose)-dependent chromatin unfolding facilitates the association of DNA-binding proteins with DNA at sites of damage
por: Smith, Rebecca, et al.
Publicado: (2019)

DNA lesions proximity modulates damage tolerance pathways in Escherichia coli
por: Chrabaszcz, Élodie, et al.
Publicado: (2018)

USP7S-dependent inactivation of Mule regulates DNA damage signalling and repair
por: Khoronenkova, Svetlana V., et al.
Publicado: (2013)

Variable interplay of UV-induced DNA damage and repair at transcription factor binding sites
por: Frigola, Joan, et al.
Publicado: (2020)

An R-loop-initiated CSB–RAD52–POLD3 pathway suppresses ROS-induced telomeric DNA breaks
por: Tan, Jun, et al.
Publicado: (2020)

Fungal Ku prevents permanent cell cycle arrest by suppressing DNA damage signaling at telomeres
por: de Sena-Tomás, Carmen, et al.
Publicado: (2015)

The role of DNA damage response pathways in chromosome fragility in Fragile X syndrome
por: Kumari, Daman, et al.
Publicado: (2009)

The helicase Pif1 functions in the template switching pathway of DNA damage bypass
por: García-Rodríguez, Néstor, et al.
Publicado: (2018)

CUX1 transcription factor is required for optimal ATM/ATR-mediated responses to DNA damage
por: Vadnais, Charles, et al.
Publicado: (2012)

The molecular basis of ATM-dependent dimerization of the Mdc1 DNA damage checkpoint mediator
por: Jungmichel, Stephanie, et al.
Publicado: (2012)

Translesion synthesis mechanisms depend on the nature of DNA damage in UV-irradiated human cells
por: Quinet, Annabel, et al.
Publicado: (2016)

Inhibition of DNA damage repair by artificial activation of PARP with siDNA
por: Croset, Amelie, et al.
Publicado: (2013)

Quantifying the stability of oxidatively damaged DNA by single-molecule DNA stretching
por: McCauley, Micah J, et al.
Publicado: (2018)

CHFR is important for the first wave of ubiquitination at DNA damage sites
por: Liu, Chao, et al.
Publicado: (2013)

Phosphorylation of polynucleotide kinase/ phosphatase by DNA-dependent protein kinase and ataxia-telangiectasia mutated regulates its association with sites of DNA damage
por: Zolner, Angela E., et al.
Publicado: (2011)

Genetic vulnerabilities upon inhibition of DNA damage response
por: Wang, Chao, et al.
Publicado: (2021)

DNA lesion identity drives choice of damage tolerance pathway in murine cell chromosomes
por: Cohen, Isadora S., et al.
Publicado: (2015)

R-loop-induced irreparable DNA damage evades checkpoint detection in the C. elegans germline
por: Hicks, Tara, et al.
Publicado: (2022)

PARG is recruited to DNA damage sites through poly(ADP-ribose)- and PCNA-dependent mechanisms
por: Mortusewicz, Oliver, et al.
Publicado: (2011)

CK2 phosphorylation-dependent interaction between aprataxin and MDC1 in the DNA damage response
por: Becherel, Olivier J., et al.
Publicado: (2010)

Chk2 and REGγ-dependent DBC1 regulation in DNA damage induced apoptosis
por: Magni, Martina, et al.
Publicado: (2014)

Evidence for lesion bypass by yeast replicative DNA polymerases during DNA damage
por: Sabouri, Nasim, et al.
Publicado: (2008)

Transcription bypass of DNA lesions enhances cell survival but attenuates transcription coupled DNA repair
por: Li, Wentao, et al.
Publicado: (2014)

8-Oxo-7,8-dihydroguanine in DNA does not constitute a barrier to transcription, but is converted into transcription-blocking damage by OGG1
por: Kitsera, Nataliya, et al.
Publicado: (2011)

OGT restrains the expansion of DNA damage signaling
por: Chen, Qiang, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_508c0f40qr2lednp0683d72n3v