JAK2(V617F) Mutation Promoted IL-6 Production and Glycolysis via Mediating PKM1 Stabilization in Macrophages

A substitution mutation of valine to phenylalanine at codon encoding position 617 of the Janus kinase 2 (JAK2) gene (JAK2(V617F)) has been detected in myeloid cells of some individuals with higher levels of proinflammatory cytokine production such as interleukin (IL)-6. However, the mechanisms by wh...

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Detalles Bibliográficos
Autores principales: Li, Rongqing, Sun, Na, Chen, Xin, Li, Xueqin, Zhao, Jie, Cheng, Wanpeng, Hua, Hui, Fukatsu, Masahiko, Mori, Hirotaka, Takahashi, Hiroshi, Ohkawara, Hiroshi, Fukami, Miwa, Okamoto, Masatoshi, Hamazaki, Yoichi, Zheng, Kuiyang, Yang, Jing, Ikezoe, Takayuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7897702/
https://www.ncbi.nlm.nih.gov/pubmed/33628203
http://dx.doi.org/10.3389/fimmu.2020.589048

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7897702/
https://www.ncbi.nlm.nih.gov/pubmed/33628203
http://dx.doi.org/10.3389/fimmu.2020.589048

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