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Proposal of selective wedge instillation of pulmonary surfactant for COVID-19 pneumonia based on computational fluid dynamics simulation

BACKGROUND: The most important target cell of SARS-CoV-2 is Type II pneumocyte which produces and secretes pulmonary surfactant (PS) that prevents alveolar collapse. PS instillation therapy is dramatically effective for infant respiratory distress syndrome but has been clinically ineffective for ARD...

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Detalles Bibliográficos
Autores principales: Kitaoka, Hiroko, Kobayashi, Hisato, Takimoto, Takayuki, Kijima, Takashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7897887/
https://www.ncbi.nlm.nih.gov/pubmed/33618696
http://dx.doi.org/10.1186/s12890-021-01435-4