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Proposal of selective wedge instillation of pulmonary surfactant for COVID-19 pneumonia based on computational fluid dynamics simulation
BACKGROUND: The most important target cell of SARS-CoV-2 is Type II pneumocyte which produces and secretes pulmonary surfactant (PS) that prevents alveolar collapse. PS instillation therapy is dramatically effective for infant respiratory distress syndrome but has been clinically ineffective for ARD...
Autores principales: | Kitaoka, Hiroko, Kobayashi, Hisato, Takimoto, Takayuki, Kijima, Takashi |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7897887/ https://www.ncbi.nlm.nih.gov/pubmed/33618696 http://dx.doi.org/10.1186/s12890-021-01435-4 |
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