Improving mitochondria and ER stability helps eliminate upper motor neuron degeneration that occurs due to mSOD1 toxicity and TDP‐43 pathology

BACKGROUND: Upper motor neurons (UMNs) are a key component of motor neuron circuitry. Their degeneration is a hallmark for diseases, such as hereditary spastic paraplegia (HSP), primary lateral sclerosis (PLS), and amyotrophic lateral sclerosis (ALS). Currently there are no preclinical assays invest...

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Detalles Bibliográficos
Autores principales: Genç, Barış, Gautam, Mukesh, Gözütok, Öge, Dervishi, Ina, Sanchez, Santana, Goshu, Gashaw M., Koçak, Nuran, Xie, Edward, Silverman, Richard B., Özdinler, P. Hande
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7898037/
https://www.ncbi.nlm.nih.gov/pubmed/33634973
http://dx.doi.org/10.1002/ctm2.336

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7898037/
https://www.ncbi.nlm.nih.gov/pubmed/33634973
http://dx.doi.org/10.1002/ctm2.336

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