Knockout of VDAC1 in H9c2 Cells Promotes Oxidative Stress-Induced Cell Apoptosis through Decreased Mitochondrial Hexokinase II Binding and Enhanced Glycolytic Stress

BACKGROUND/AIMS: The role of VDAC1, the most abundant mitochondrial outer membrane protein, in cell death depends on cell types and stimuli. Both silencing and upregulation of VDAC1 in various type of cancer cell lines can stimulate apoptosis. In contrast, in mouse embryonic stem (MES) cells and mou...

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Detalles Bibliográficos
Autores principales: Yang, Meiying, Sun, Jie, Stowe, David F., Tajkhorshid, Emad, Kwok, Wai-Meng, Camara, Amadou K. S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7898235/
https://www.ncbi.nlm.nih.gov/pubmed/32901466
http://dx.doi.org/10.33594/000000274

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7898235/
https://www.ncbi.nlm.nih.gov/pubmed/32901466
http://dx.doi.org/10.33594/000000274

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