Identifying Drug Response by Combining Measurements of the Membrane Potential, the Cytosolic Calcium Concentration, and the Extracellular Potential in Microphysiological Systems

Cardiomyocytes derived from human induced pluripotent stem cells (hiPSC-CMs) offer a new means to study and understand the human cardiac action potential, and can give key insight into how compounds may interact with important molecular pathways to destabilize the electrical function of the heart. I...

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Detalles Bibliográficos
Autores principales: Jæger, Karoline Horgmo, Charwat, Verena, Wall, Samuel, Healy, Kevin E., Tveito, Aslak
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7898238/
https://www.ncbi.nlm.nih.gov/pubmed/33628168
http://dx.doi.org/10.3389/fphar.2020.569489

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7898238/
https://www.ncbi.nlm.nih.gov/pubmed/33628168
http://dx.doi.org/10.3389/fphar.2020.569489

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