Generation of Oxidoreductases with Dual Alcohol Dehydrogenase and Amine Dehydrogenase Activity

The l‐lysine‐ϵ‐dehydrogenase (LysEDH) from Geobacillus stearothermophilus naturally catalyzes the oxidative deamination of the ϵ‐amino group of l‐lysine. We previously engineered this enzyme to create amine dehydrogenase (AmDH) variants that possess a new hydrophobic cavity in their active site such...

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Detalles Bibliográficos
Autores principales: Tseliou, Vasilis, Schilder, Don, Masman, Marcelo F., Knaus, Tanja, Mutti, Francesco G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Full Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7898336/
https://www.ncbi.nlm.nih.gov/pubmed/33073866
http://dx.doi.org/10.1002/chem.202003140

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7898336/
https://www.ncbi.nlm.nih.gov/pubmed/33073866
http://dx.doi.org/10.1002/chem.202003140

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