Structural Basis of the Modulation of the Voltage‐Gated Calcium Ion Channel Ca(v)1.1 by Dihydropyridine Compounds

1,4‐Dihydropyridines (DHP), the most commonly used antihypertensives, function by inhibiting the L‐type voltage‐gated Ca(2+) (Ca(v)) channels. DHP compounds exhibit chirality‐specific antagonistic or agonistic effects. The structure of rabbit Ca(v)1.1 bound to an achiral drug nifedipine reveals the...

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Detalles Bibliográficos
Autores principales: Gao, Shuai, Yan, Nieng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7898392/
https://www.ncbi.nlm.nih.gov/pubmed/33125829
http://dx.doi.org/10.1002/anie.202011793

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7898392/
https://www.ncbi.nlm.nih.gov/pubmed/33125829
http://dx.doi.org/10.1002/anie.202011793

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