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Structural Basis of the Modulation of the Voltage‐Gated Calcium Ion Channel Ca(v)1.1 by Dihydropyridine Compounds
1,4‐Dihydropyridines (DHP), the most commonly used antihypertensives, function by inhibiting the L‐type voltage‐gated Ca(2+) (Ca(v)) channels. DHP compounds exhibit chirality‐specific antagonistic or agonistic effects. The structure of rabbit Ca(v)1.1 bound to an achiral drug nifedipine reveals the...
Autores principales: | Gao, Shuai, Yan, Nieng |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7898392/ https://www.ncbi.nlm.nih.gov/pubmed/33125829 http://dx.doi.org/10.1002/anie.202011793 |
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