TrkA-mediated endocytosis of p75-CTF prevents cholinergic neuron death upon γ-secretase inhibition

γ-secretase inhibitors (GSI) were developed to reduce the generation of Aβ peptide to find new Alzheimer’s disease treatments. Clinical trials on Alzheimer’s disease patients, however, showed several side effects that worsened the cognitive symptoms of the treated patients. The observed side effects...

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Detalles Bibliográficos
Autores principales: Franco, María Luisa, García-Carpio, Irmina, Comaposada-Baró, Raquel, Escribano-Saiz, Juan J, Chávez-Gutiérrez, Lucía, Vilar, Marçal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Life Science Alliance LLC 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7898468/
https://www.ncbi.nlm.nih.gov/pubmed/33536237
http://dx.doi.org/10.26508/lsa.202000844

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7898468/
https://www.ncbi.nlm.nih.gov/pubmed/33536237
http://dx.doi.org/10.26508/lsa.202000844

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