Sirolimus augments hematopoietic stem and progenitor cell regeneration following hematopoietic insults

The role of mammalian target of rapamycin and its suppressor sirolimus in the regulation of hematopoietic stem and progenitor cells (HSPCs) is controversial. We show here that sirolimus enhanced regeneration of HSPCs in mice exposed to sublethal total body irradiation (TBI) and other regenerative st...

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Detalles Bibliográficos
Autores principales: Lin, Zenghua, Hollinger, Maile K., Wu, Zhijie, Sun, Wanling, Batey, Kaylind, Kim, Jisoo, Chen, Jichun, Feng, Xingmin, Young, Neal S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2020
Materias:
Translational and Clinical Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7898520/
https://www.ncbi.nlm.nih.gov/pubmed/33270949
http://dx.doi.org/10.1002/stem.3313

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7898520/
https://www.ncbi.nlm.nih.gov/pubmed/33270949
http://dx.doi.org/10.1002/stem.3313

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