Timosaponin AIII Induces G2/M Arrest and Apoptosis in Breast Cancer by Activating the ATM/Chk2 and p38 MAPK Signaling Pathways

Timosaponin AIII (TAIII), a steroidal saponin, exerts potent anti-tumor activity in various cancers, especially breast cancer. However, the concrete molecular mechanisms of TAIII against breast cancer are still unclear. Here, we find that TAIII triggers DNA damage, leads to G2/M arrest, and ultimate...

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Detalles Bibliográficos
Autores principales: Zhang, Minjie, Qu, Jiaxi, Gao, Zhiwei, Qi, Qi, Yin, Hong, Zhu, Ling, Wu, Yichen, Liu, Wei, Yang, Jian, Huang, Xuefeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7898553/
https://www.ncbi.nlm.nih.gov/pubmed/33628174
http://dx.doi.org/10.3389/fphar.2020.601468

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7898553/
https://www.ncbi.nlm.nih.gov/pubmed/33628174
http://dx.doi.org/10.3389/fphar.2020.601468

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