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Phenotypic Discovery of Neuroprotective Agents by Regulation of Tau Proteostasis via Stress‐Responsive Activation of PERK Signaling

Tau protein aggregates are a recognized neuropathological feature in Alzheimer's disease as well as many other neurodegenerative disorders, known as tauopathies. The development of tau‐targeting therapies is therefore extremely important but efficient strategies or protein targets are still unc...

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Detalles Bibliográficos
Autores principales: Shin, Young‐Hee, Cho, Hana, Choi, Bo Young, Kim, Jonghoon, Ha, Jaeyoung, Suh, Sang Won, Park, Seung Bum
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7898623/
https://www.ncbi.nlm.nih.gov/pubmed/33210431
http://dx.doi.org/10.1002/anie.202013915