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Forty Years after the Discovery of Its Nucleolytic Activity: [Cu(phen)(2)](2+) Shows Unattended DNA Cleavage Activity upon Fluorination

[Cu(phen)(2)](2+) (phen=1,10‐phenanthroline) is the first and still one of the most efficient artificial nucleases. In general, when the phen ligand is modified, the nucleolytic activity of its Cu(II) complex is significantly reduced. This is most likely due to higher steric bulk of such ligands and...

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Detalles Bibliográficos
Autores principales: Lüdtke, Carsten, Sobottka, Sebastian, Heinrich, Julian, Liebing, Phil, Wedepohl, Stefanie, Sarkar, Biprajit, Kulak, Nora
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7898652/
https://www.ncbi.nlm.nih.gov/pubmed/33245157
http://dx.doi.org/10.1002/chem.202004594