Polymeric nanoencapsulation of zaleplon into PLGA nanoparticles for enhanced pharmacokinetics and pharmacological activity

Zaleplon (ZP) is a sedative and hypnotic drug used for the treatment of insomnia. Despite its potent anticonvulsant activity, ZP is not commonly used for the treatment of convulsion since ZP is characterized by its low oral bioavailability as a result of poor solubility and extensive liver metabolis...

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Detalles Bibliográficos
Autores principales: Haggag, Yusuf A., Abosalha, Ahmed Kh., Tambuwala, Murtaza M., Osman, Enass Y., El‐Gizawy, Sanaa A., Essa, Ebtessam A., Donia, Ahmed A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Original Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7898708/
https://www.ncbi.nlm.nih.gov/pubmed/33320969
http://dx.doi.org/10.1002/bdd.2255

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7898708/
https://www.ncbi.nlm.nih.gov/pubmed/33320969
http://dx.doi.org/10.1002/bdd.2255

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