Protofibril–Fibril Interactions Inhibit Amyloid Fibril Assembly by Obstructing Secondary Nucleation

Amyloid‐β peptides (Aβ) assemble into both rigid amyloid fibrils and metastable oligomers termed AβO or protofibrils. In Alzheimer's disease, Aβ fibrils constitute the core of senile plaques, but Aβ protofibrils may represent the main toxic species. Aβ protofibrils accumulate at the exterior of...

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Detalles Bibliográficos
Autores principales: Hasecke, Filip, Niyangoda, Chamani, Borjas, Gustavo, Pan, Jianjun, Matthews, Garrett, Muschol, Martin, Hoyer, Wolfgang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7898819/
https://www.ncbi.nlm.nih.gov/pubmed/33095508
http://dx.doi.org/10.1002/anie.202010098

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7898819/
https://www.ncbi.nlm.nih.gov/pubmed/33095508
http://dx.doi.org/10.1002/anie.202010098

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