Cargando…

SNPs associated with colorectal cancer at 15q13.3 affect risk enhancers that modulate GREM1 gene expression

Several genome wide association studies of colorectal cancer (CRC) have identified single nucleotide polymorphisms (SNPs) on chromosome 15q13.3 associated with CRC risk. To identify functional variant(s) underlying this association, we investigated SNPs in linkage disequilibrium with the risk‐associ...

Descripción completa

Detalles Bibliográficos
Autores principales:	Fortini, Barbara K., Tring, Stephanie, Devall, Matthew A., Ali, Mourad Wagdy, Plummer, Sarah J., Casey, Graham
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2021
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7898835/ https://www.ncbi.nlm.nih.gov/pubmed/33476087 http://dx.doi.org/10.1002/humu.24166

Ejemplares similares

The psychiatric phenotype of 15q11.2-q13.3 duplications
por: Budisteanu, M., et al.
Publicado: (2021)

A Functional Variant on 9p21.3 Related to Glioma Risk Affects Enhancer Activity and Modulates Expression of CDKN2B‐AS1
por: Ali, Mourad Wagdy, et al.
Publicado: (2021)

Multiple Functional Risk Variants in a SMAD7 Enhancer Implicate a Colorectal Cancer Risk Haplotype
por: Fortini, Barbara K., et al.
Publicado: (2014)

15q13.3 duplication in two patients with childhood‐onset schizophrenia
por: Zhou, Dale, et al.
Publicado: (2016)

GREM 1 and POLE variants in hereditary colorectal cancer syndromes
por: Rohlin, Anna, et al.
Publicado: (2015)

The Phenotypic Spectrum of 15q13.3 Region Duplications: Report of 5 Patients
por: Budisteanu, Magdalena, et al.
Publicado: (2021)

A functional variant on 20q13.33 related to glioma risk alters enhancer activity and modulates expression of multiple genes
por: Ali, Mourad Wagdy, et al.
Publicado: (2020)

Parental Origin of Interstitial Duplications at 15q11.2-q13.3 in Schizophrenia and Neurodevelopmental Disorders
por: Isles, Anthony R., et al.
Publicado: (2016)

Microduplication of 15q13.3 and Microdeletion of 18q21.32 in a Patient with Moyamoya Syndrome
por: Luisa, Sciacca Francesca, et al.
Publicado: (2018)

Deletion 22q13.3 syndrome
por: Phelan, Mary C
Publicado: (2008)

Absence seizures with intellectual disability as a phenotype of the 15q13.3 microdeletion syndrome
por: Muhle, Hiltrud, et al.
Publicado: (2011)

OTUD7A Regulates Neurodevelopmental Phenotypes in the 15q13.3 Microdeletion Syndrome
por: Uddin, Mohammed, et al.
Publicado: (2018)

Is Chromosome 15q13.3 Duplication Involving CHRNA7 Associated With Oral Clefts?
por: Xie, Yingjun
Publicado: (2015)

Case reports of two siblings with autism spectrum disorder and 15q13.3 deletions
por: Furukawa, Sawako, et al.
Publicado: (2023)

Meta-analysis Reveals Genome-Wide Significance at 15q13 for Nonsyndromic Clefting of Both the Lip and the Palate, and Functional Analyses Implicate GREM1 As a Plausible Causative Gene
por: Ludwig, Kerstin U., et al.
Publicado: (2016)

Chipping away at the common epilepsies with complex genetics: the 15q13.3 microdeletion shows the way
por: Mulley, John C, et al.
Publicado: (2009)

Septo-optic dysplasia associated with chromosome 15q13.3 duplication: a case report
por: Ham, Jeong A, et al.
Publicado: (2022)

BMP signalling in human fetal ovary somatic cells is modulated in a gene-specific fashion by GREM1 and GREM2
por: Bayne, Rosemary A., et al.
Publicado: (2016)

Transcriptomic Response to Calcium in Normal Colon Organoids is Impacted by Colon Location and Sex
por: Devall, Matthew A.M., et al.
Publicado: (2022)

An Inherited Small Microdeletion at 15q13.3 in a Patient with Early- Onset Obsessive-Compulsive Disorder
por: Cappi, Carolina, et al.
Publicado: (2014)

Palindromic GOLGA8 core duplicons promote chromosome 15q13.3 microdeletion and evolutionary instability
por: Antonacci, Francesca, et al.
Publicado: (2014)

15q13.3 homozygous knockout mouse model display epilepsy-, autism- and schizophrenia-related phenotypes
por: Forsingdal, A, et al.
Publicado: (2016)

Altered gene expression profiles impair the nervous system development in individuals with 15q13.3 microdeletion
por: Körner, Marek B., et al.
Publicado: (2022)

Colorectal Cancer Linkage on Chromosomes 4q21, 8q13, 12q24, and 15q22
por: Cicek, Mine S., et al.
Publicado: (2012)

Correction: Colorectal Cancer Linkage on Chromosomes 4q21, 8q13, 12q24, and 15q22
por: Cicek, Mine S., et al.
Publicado: (2012)

A mouse model of the 15q13.3 microdeletion syndrome shows prefrontal neurophysiological dysfunctions and attentional impairment
por: Nilsson, Simon R. O., et al.
Publicado: (2016)

Screening for Copy Number Variations of the 15q13.3 Hotspot in CHRNA7 Gene and Expression in Patients with Migraines
por: Özaltun, Mehmet Fatih, et al.
Publicado: (2021)

DNA methylation analysis of normal colon organoids from familial adenomatous polyposis patients reveals novel insight into colon cancer development
por: Devall, Matthew A., et al.
Publicado: (2022)

Insights into Early Onset Colorectal Cancer through Analysis of Normal Colon Organoids of Familial Adenomatous Polyposis Patients
por: Devall, Matthew A., et al.
Publicado: (2022)

First report of two successive deletions on chromosome 15q13 cytogenetic bands in a boy and girl: additional data to 15q13.3 syndrome with a report of high IQ patient
por: Alsagob, Maysoon, et al.
Publicado: (2019)

A Genetic Locus within the FMN1/GREM1 Gene Region Interacts with Body Mass Index in Colorectal Cancer Risk
por: Aglago, Elom K., et al.
Publicado: (2023)

Oncogenic Features in Histologically Normal Mucosa: Novel Insights Into Field Effect From a Mega-Analysis of Colorectal Transcriptomes
por: Dampier, Christopher H., et al.
Publicado: (2020)

11q13.3q13.4 deletion plus 9q21.13q21.33 duplication in an affected girl arising from a familial four‐way balanced chromosomal translocation
por: Zhang, Qinxin, et al.
Publicado: (2023)

Homozygous 15q13.3 microdeletion in a child with hypotonia and impaired vision: A new report and review of the literature
por: Simon, Julie, et al.
Publicado: (2019)

Controlling for cellular heterogeneity using single-cell deconvolution of gene expression reveals novel markers of colorectal tumors exhibiting microsatellite instability
por: Devall, Matthew A.M., et al.
Publicado: (2021)

Allelic Depletion of grem1 Attenuates Diabetic Kidney Disease
por: Roxburgh, Sarah A., et al.
Publicado: (2009)

Current status and prospects of GREM1 research in cancer (Review)
por: Zhu, Dantong, et al.
Publicado: (2023)

MiR-103a-3p Contributes to the Progression of Colorectal Cancer by Regulating GREM2 Expression
por: Zhang, Zongxiang, et al.
Publicado: (2022)

Combined 22q11.1-q11.21 deletion with 15q11.2-q13.3 duplication identified by array-CGH in a 6 years old boy
por: Manolakos, Emmanouil, et al.
Publicado: (2011)

Combined 22q11.1-q11.21 deletion with 15q11.2-q13.3 duplication identified by array-CGH in a 6 years old boy
por: Manolakos, Emmanouil, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_e2elg6setjkp5dqhjdf97ffkv4