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Tag‐Free Internal RNA Labeling and Photocaging Based on mRNA Methyltransferases

The mRNA modification N(6)‐methyladenosine (m(6)A) is associated with multiple roles in cell function and disease. The methyltransferases METTL3‐METTL14 and METTL16 act as “writers” for different target transcripts and sequence motifs. The modification is perceived by dedicated “reader” and “eraser”...

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Detalles Bibliográficos
Autores principales: Ovcharenko, Anna, Weissenboeck, Florian P., Rentmeister, Andrea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7898847/
https://www.ncbi.nlm.nih.gov/pubmed/33095964
http://dx.doi.org/10.1002/anie.202013936