Autophagosome maturation stymied by SARS-CoV-2

Many pathogens are capable of disrupting autophagy within host cells. In this issue of Developmental Cell, Miao et al. discover that the SARS-CoV-2 protein ORF3a inhibits autophagosome-lysosome fusion by dysregulating the HOPS complex.

Detalles Bibliográficos
Autores principales: Yim, Willa Wen-You, Mizushima, Noboru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2021
Materias:
Preview
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7898975/
https://www.ncbi.nlm.nih.gov/pubmed/33621488
http://dx.doi.org/10.1016/j.devcel.2021.02.002
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author Yim, Willa Wen-You
Mizushima, Noboru
author_facet Yim, Willa Wen-You
Mizushima, Noboru
author_sort Yim, Willa Wen-You
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description Many pathogens are capable of disrupting autophagy within host cells. In this issue of Developmental Cell, Miao et al. discover that the SARS-CoV-2 protein ORF3a inhibits autophagosome-lysosome fusion by dysregulating the HOPS complex.
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spelling pubmed-78989752021-02-23 Autophagosome maturation stymied by SARS-CoV-2 Yim, Willa Wen-You Mizushima, Noboru Dev Cell Preview Many pathogens are capable of disrupting autophagy within host cells. In this issue of Developmental Cell, Miao et al. discover that the SARS-CoV-2 protein ORF3a inhibits autophagosome-lysosome fusion by dysregulating the HOPS complex. Elsevier Inc. 2021-02-22 2021-02-22 /pmc/articles/PMC7898975/ /pubmed/33621488 http://dx.doi.org/10.1016/j.devcel.2021.02.002 Text en © 2021 Elsevier Inc. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Preview
Yim, Willa Wen-You
Mizushima, Noboru
Autophagosome maturation stymied by SARS-CoV-2
title Autophagosome maturation stymied by SARS-CoV-2
title_full Autophagosome maturation stymied by SARS-CoV-2
title_fullStr Autophagosome maturation stymied by SARS-CoV-2
title_full_unstemmed Autophagosome maturation stymied by SARS-CoV-2
title_short Autophagosome maturation stymied by SARS-CoV-2
title_sort autophagosome maturation stymied by sars-cov-2
topic Preview
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7898975/
https://www.ncbi.nlm.nih.gov/pubmed/33621488
http://dx.doi.org/10.1016/j.devcel.2021.02.002
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