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The Second NINDS/NIBIB Consensus Meeting to Define Neuropathological Criteria for the Diagnosis of Chronic Traumatic Encephalopathy
Chronic traumatic encephalopathy (CTE) is a neurodegenerative disorder associated with exposure to head trauma. In 2015, a panel of neuropathologists funded by the NINDS/NIBIB defined preliminary consensus neuropathological criteria for CTE, including the pathognomonic lesion of CTE as “an accumulat...
Autores principales: | , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7899277/ https://www.ncbi.nlm.nih.gov/pubmed/33611507 http://dx.doi.org/10.1093/jnen/nlab001 |
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author | Bieniek, Kevin F Cairns, Nigel J Crary, John F Dickson, Dennis W Folkerth, Rebecca D Keene, C Dirk Litvan, Irene Perl, Daniel P Stein, Thor D Vonsattel, Jean-Paul Stewart, William Dams-O’Connor, Kristen Gordon, Wayne A Tripodis, Yorghos Alvarez, Victor E Mez, Jesse Alosco, Michael L McKee, Ann C |
author_facet | Bieniek, Kevin F Cairns, Nigel J Crary, John F Dickson, Dennis W Folkerth, Rebecca D Keene, C Dirk Litvan, Irene Perl, Daniel P Stein, Thor D Vonsattel, Jean-Paul Stewart, William Dams-O’Connor, Kristen Gordon, Wayne A Tripodis, Yorghos Alvarez, Victor E Mez, Jesse Alosco, Michael L McKee, Ann C |
author_sort | Bieniek, Kevin F |
collection | PubMed |
description | Chronic traumatic encephalopathy (CTE) is a neurodegenerative disorder associated with exposure to head trauma. In 2015, a panel of neuropathologists funded by the NINDS/NIBIB defined preliminary consensus neuropathological criteria for CTE, including the pathognomonic lesion of CTE as “an accumulation of abnormal hyperphosphorylated tau (p-tau) in neurons and astroglia distributed around small blood vessels at the depths of cortical sulci and in an irregular pattern,” based on review of 25 tauopathy cases. In 2016, the consensus panel met again to review and refine the preliminary criteria, with consideration around the minimum threshold for diagnosis and the reproducibility of a proposed pathological staging scheme. Eight neuropathologists evaluated 27 cases of tauopathies (17 CTE cases), blinded to clinical and demographic information. Generalized estimating equation analyses showed a statistically significant association between the raters and CTE diagnosis for both the blinded (OR = 72.11, 95% CI = 19.5–267.0) and unblinded rounds (OR = 256.91, 95% CI = 63.6–1558.6). Based on the challenges in assigning CTE stage, the panel proposed a working protocol including a minimum threshold for CTE diagnosis and an algorithm for the assessment of CTE severity as “Low CTE” or “High CTE” for use in future clinical, pathological, and molecular studies. |
format | Online Article Text |
id | pubmed-7899277 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-78992772022-02-20 The Second NINDS/NIBIB Consensus Meeting to Define Neuropathological Criteria for the Diagnosis of Chronic Traumatic Encephalopathy Bieniek, Kevin F Cairns, Nigel J Crary, John F Dickson, Dennis W Folkerth, Rebecca D Keene, C Dirk Litvan, Irene Perl, Daniel P Stein, Thor D Vonsattel, Jean-Paul Stewart, William Dams-O’Connor, Kristen Gordon, Wayne A Tripodis, Yorghos Alvarez, Victor E Mez, Jesse Alosco, Michael L McKee, Ann C J Neuropathol Exp Neurol Original Articles Chronic traumatic encephalopathy (CTE) is a neurodegenerative disorder associated with exposure to head trauma. In 2015, a panel of neuropathologists funded by the NINDS/NIBIB defined preliminary consensus neuropathological criteria for CTE, including the pathognomonic lesion of CTE as “an accumulation of abnormal hyperphosphorylated tau (p-tau) in neurons and astroglia distributed around small blood vessels at the depths of cortical sulci and in an irregular pattern,” based on review of 25 tauopathy cases. In 2016, the consensus panel met again to review and refine the preliminary criteria, with consideration around the minimum threshold for diagnosis and the reproducibility of a proposed pathological staging scheme. Eight neuropathologists evaluated 27 cases of tauopathies (17 CTE cases), blinded to clinical and demographic information. Generalized estimating equation analyses showed a statistically significant association between the raters and CTE diagnosis for both the blinded (OR = 72.11, 95% CI = 19.5–267.0) and unblinded rounds (OR = 256.91, 95% CI = 63.6–1558.6). Based on the challenges in assigning CTE stage, the panel proposed a working protocol including a minimum threshold for CTE diagnosis and an algorithm for the assessment of CTE severity as “Low CTE” or “High CTE” for use in future clinical, pathological, and molecular studies. Oxford University Press 2021-02-21 /pmc/articles/PMC7899277/ /pubmed/33611507 http://dx.doi.org/10.1093/jnen/nlab001 Text en © 2021 American Association of Neuropathologists, Inc. https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_modelThis is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
spellingShingle | Original Articles Bieniek, Kevin F Cairns, Nigel J Crary, John F Dickson, Dennis W Folkerth, Rebecca D Keene, C Dirk Litvan, Irene Perl, Daniel P Stein, Thor D Vonsattel, Jean-Paul Stewart, William Dams-O’Connor, Kristen Gordon, Wayne A Tripodis, Yorghos Alvarez, Victor E Mez, Jesse Alosco, Michael L McKee, Ann C The Second NINDS/NIBIB Consensus Meeting to Define Neuropathological Criteria for the Diagnosis of Chronic Traumatic Encephalopathy |
title | The Second NINDS/NIBIB Consensus Meeting to Define Neuropathological Criteria for the Diagnosis of Chronic Traumatic Encephalopathy |
title_full | The Second NINDS/NIBIB Consensus Meeting to Define Neuropathological Criteria for the Diagnosis of Chronic Traumatic Encephalopathy |
title_fullStr | The Second NINDS/NIBIB Consensus Meeting to Define Neuropathological Criteria for the Diagnosis of Chronic Traumatic Encephalopathy |
title_full_unstemmed | The Second NINDS/NIBIB Consensus Meeting to Define Neuropathological Criteria for the Diagnosis of Chronic Traumatic Encephalopathy |
title_short | The Second NINDS/NIBIB Consensus Meeting to Define Neuropathological Criteria for the Diagnosis of Chronic Traumatic Encephalopathy |
title_sort | second ninds/nibib consensus meeting to define neuropathological criteria for the diagnosis of chronic traumatic encephalopathy |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7899277/ https://www.ncbi.nlm.nih.gov/pubmed/33611507 http://dx.doi.org/10.1093/jnen/nlab001 |
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