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The Second NINDS/NIBIB Consensus Meeting to Define Neuropathological Criteria for the Diagnosis of Chronic Traumatic Encephalopathy

Chronic traumatic encephalopathy (CTE) is a neurodegenerative disorder associated with exposure to head trauma. In 2015, a panel of neuropathologists funded by the NINDS/NIBIB defined preliminary consensus neuropathological criteria for CTE, including the pathognomonic lesion of CTE as “an accumulat...

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Autores principales: Bieniek, Kevin F, Cairns, Nigel J, Crary, John F, Dickson, Dennis W, Folkerth, Rebecca D, Keene, C Dirk, Litvan, Irene, Perl, Daniel P, Stein, Thor D, Vonsattel, Jean-Paul, Stewart, William, Dams-O’Connor, Kristen, Gordon, Wayne A, Tripodis, Yorghos, Alvarez, Victor E, Mez, Jesse, Alosco, Michael L, McKee, Ann C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7899277/
https://www.ncbi.nlm.nih.gov/pubmed/33611507
http://dx.doi.org/10.1093/jnen/nlab001
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author Bieniek, Kevin F
Cairns, Nigel J
Crary, John F
Dickson, Dennis W
Folkerth, Rebecca D
Keene, C Dirk
Litvan, Irene
Perl, Daniel P
Stein, Thor D
Vonsattel, Jean-Paul
Stewart, William
Dams-O’Connor, Kristen
Gordon, Wayne A
Tripodis, Yorghos
Alvarez, Victor E
Mez, Jesse
Alosco, Michael L
McKee, Ann C
author_facet Bieniek, Kevin F
Cairns, Nigel J
Crary, John F
Dickson, Dennis W
Folkerth, Rebecca D
Keene, C Dirk
Litvan, Irene
Perl, Daniel P
Stein, Thor D
Vonsattel, Jean-Paul
Stewart, William
Dams-O’Connor, Kristen
Gordon, Wayne A
Tripodis, Yorghos
Alvarez, Victor E
Mez, Jesse
Alosco, Michael L
McKee, Ann C
author_sort Bieniek, Kevin F
collection PubMed
description Chronic traumatic encephalopathy (CTE) is a neurodegenerative disorder associated with exposure to head trauma. In 2015, a panel of neuropathologists funded by the NINDS/NIBIB defined preliminary consensus neuropathological criteria for CTE, including the pathognomonic lesion of CTE as “an accumulation of abnormal hyperphosphorylated tau (p-tau) in neurons and astroglia distributed around small blood vessels at the depths of cortical sulci and in an irregular pattern,” based on review of 25 tauopathy cases. In 2016, the consensus panel met again to review and refine the preliminary criteria, with consideration around the minimum threshold for diagnosis and the reproducibility of a proposed pathological staging scheme. Eight neuropathologists evaluated 27 cases of tauopathies (17 CTE cases), blinded to clinical and demographic information. Generalized estimating equation analyses showed a statistically significant association between the raters and CTE diagnosis for both the blinded (OR = 72.11, 95% CI = 19.5–267.0) and unblinded rounds (OR = 256.91, 95% CI = 63.6–1558.6). Based on the challenges in assigning CTE stage, the panel proposed a working protocol including a minimum threshold for CTE diagnosis and an algorithm for the assessment of CTE severity as “Low CTE” or “High CTE” for use in future clinical, pathological, and molecular studies.
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spelling pubmed-78992772022-02-20 The Second NINDS/NIBIB Consensus Meeting to Define Neuropathological Criteria for the Diagnosis of Chronic Traumatic Encephalopathy Bieniek, Kevin F Cairns, Nigel J Crary, John F Dickson, Dennis W Folkerth, Rebecca D Keene, C Dirk Litvan, Irene Perl, Daniel P Stein, Thor D Vonsattel, Jean-Paul Stewart, William Dams-O’Connor, Kristen Gordon, Wayne A Tripodis, Yorghos Alvarez, Victor E Mez, Jesse Alosco, Michael L McKee, Ann C J Neuropathol Exp Neurol Original Articles Chronic traumatic encephalopathy (CTE) is a neurodegenerative disorder associated with exposure to head trauma. In 2015, a panel of neuropathologists funded by the NINDS/NIBIB defined preliminary consensus neuropathological criteria for CTE, including the pathognomonic lesion of CTE as “an accumulation of abnormal hyperphosphorylated tau (p-tau) in neurons and astroglia distributed around small blood vessels at the depths of cortical sulci and in an irregular pattern,” based on review of 25 tauopathy cases. In 2016, the consensus panel met again to review and refine the preliminary criteria, with consideration around the minimum threshold for diagnosis and the reproducibility of a proposed pathological staging scheme. Eight neuropathologists evaluated 27 cases of tauopathies (17 CTE cases), blinded to clinical and demographic information. Generalized estimating equation analyses showed a statistically significant association between the raters and CTE diagnosis for both the blinded (OR = 72.11, 95% CI = 19.5–267.0) and unblinded rounds (OR = 256.91, 95% CI = 63.6–1558.6). Based on the challenges in assigning CTE stage, the panel proposed a working protocol including a minimum threshold for CTE diagnosis and an algorithm for the assessment of CTE severity as “Low CTE” or “High CTE” for use in future clinical, pathological, and molecular studies. Oxford University Press 2021-02-21 /pmc/articles/PMC7899277/ /pubmed/33611507 http://dx.doi.org/10.1093/jnen/nlab001 Text en © 2021 American Association of Neuropathologists, Inc. https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_modelThis is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Original Articles
Bieniek, Kevin F
Cairns, Nigel J
Crary, John F
Dickson, Dennis W
Folkerth, Rebecca D
Keene, C Dirk
Litvan, Irene
Perl, Daniel P
Stein, Thor D
Vonsattel, Jean-Paul
Stewart, William
Dams-O’Connor, Kristen
Gordon, Wayne A
Tripodis, Yorghos
Alvarez, Victor E
Mez, Jesse
Alosco, Michael L
McKee, Ann C
The Second NINDS/NIBIB Consensus Meeting to Define Neuropathological Criteria for the Diagnosis of Chronic Traumatic Encephalopathy
title The Second NINDS/NIBIB Consensus Meeting to Define Neuropathological Criteria for the Diagnosis of Chronic Traumatic Encephalopathy
title_full The Second NINDS/NIBIB Consensus Meeting to Define Neuropathological Criteria for the Diagnosis of Chronic Traumatic Encephalopathy
title_fullStr The Second NINDS/NIBIB Consensus Meeting to Define Neuropathological Criteria for the Diagnosis of Chronic Traumatic Encephalopathy
title_full_unstemmed The Second NINDS/NIBIB Consensus Meeting to Define Neuropathological Criteria for the Diagnosis of Chronic Traumatic Encephalopathy
title_short The Second NINDS/NIBIB Consensus Meeting to Define Neuropathological Criteria for the Diagnosis of Chronic Traumatic Encephalopathy
title_sort second ninds/nibib consensus meeting to define neuropathological criteria for the diagnosis of chronic traumatic encephalopathy
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7899277/
https://www.ncbi.nlm.nih.gov/pubmed/33611507
http://dx.doi.org/10.1093/jnen/nlab001
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