Biomarker-focused multi-drug combination therapy and repurposing trial in mdx mice

Duchenne muscular dystrophy is initiated by dystrophin deficiency, but downstream pathophysiological pathways such as membrane instability, NFĸB activation, mitochondrial dysfunction, and induction of TGFβ fibrosis pathways are thought to drive the disability. Dystrophin replacement strategies are h...

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Detalles Bibliográficos
Autores principales: Ziemba, Michael, Barkhouse, Molly, Uaesoontrachoon, Kitipong, Giri, Mamta, Hathout, Yetrib, Dang, Utkarsh J., Gordish-Dressman, Heather, Nagaraju, Kanneboyina, Hoffman, Eric P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7899329/
https://www.ncbi.nlm.nih.gov/pubmed/33617542
http://dx.doi.org/10.1371/journal.pone.0246507

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7899329/
https://www.ncbi.nlm.nih.gov/pubmed/33617542
http://dx.doi.org/10.1371/journal.pone.0246507

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