Genome-wide analysis in 756,646 individuals provides first genetic evidence that ACE2 expression influences COVID-19 risk and yields genetic risk scores predictive of severe disease

SARS-CoV-2 enters host cells by binding angiotensin-converting enzyme 2 (ACE2). Through a genome-wide association study, we show that a rare variant (MAF = 0.3%, odds ratio 0.60, P=4.5×10(−13)) that down-regulates ACE2 expression reduces risk of COVID-19 disease, providing human genetics support for...

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Detalles Bibliográficos
Autores principales: Horowitz, J. E., Kosmicki, J. A., Damask, A., Sharma, D., Roberts, G. H. L., Justice, A. E., Banerjee, N., Coignet, M. V., Yadav, A., Leader, J. B., Marcketta, A., Park, D. S., Lanche, R., Maxwell, E., Knight, S. C., Bai, X., Guturu, H., Sun, D., Baltzell, A., Kury, F. S. P., Backman, J. D., Girshick, A. R., O’Dushlaine, C., McCurdy, S. R., Partha, R., Mansfield, A. J., Turissini, D. A., Li, A. H., Zhang, M., Mbatchou, J., Watanabe, K., Gurski, L., McCarthy, S. E., Kang, H. M., Dobbyn, L., Stahl, E., Verma, A., Sirugo, G., Ritchie, M. D., Jones, M., Balasubramanian, S., Siminovitch, K., Salerno, W. J., Shuldiner, A. R., Rader, D. J., Mirshahi, T., Locke, A. E., Marchini, J., Overton, J. D., Carey, D. J., Habegger, L., Cantor, M. N., Rand, K. A., Hong, E. L., Reid, J. G., Ball, C. A., Baras, A., Abecasis, G. R., Ferreira, M. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7899471/
https://www.ncbi.nlm.nih.gov/pubmed/33619501
http://dx.doi.org/10.1101/2020.12.14.20248176

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7899471/
https://www.ncbi.nlm.nih.gov/pubmed/33619501
http://dx.doi.org/10.1101/2020.12.14.20248176

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