Intratumoral immunotherapy with STING agonist, ADU-S100, induces CD8+ T-cell mediated anti-tumor immunity in an esophageal adenocarcinoma model

Background: Esophageal adenocarcinoma (EAC) is a deadly disease with limited treatment options. STING is a transmembrane protein that activates transcription of interferon genes, resulting in stimulation of APCs and enhanced CD8+ T-cell infiltration. The present study evaluates STING agonists, alone...

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Detalles Bibliográficos
Autores principales: Zaidi, Ali H., Kelly, Ronan J., Gorbunova, Anastasia, Omstead, Ashten N., Salvitti, Madison S., Zheng, Ping, Kosovec, Juliann E., Lee, Soyoung, Ayazi, Shahin, Babar, Laila, Finley, Gene G., Goel, Ajay, Jobe, Blair A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7899550/
https://www.ncbi.nlm.nih.gov/pubmed/33659041
http://dx.doi.org/10.18632/oncotarget.27886

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7899550/
https://www.ncbi.nlm.nih.gov/pubmed/33659041
http://dx.doi.org/10.18632/oncotarget.27886

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