Cargando…

Intratumoral immunotherapy with STING agonist, ADU-S100, induces CD8+ T-cell mediated anti-tumor immunity in an esophageal adenocarcinoma model

Background: Esophageal adenocarcinoma (EAC) is a deadly disease with limited treatment options. STING is a transmembrane protein that activates transcription of interferon genes, resulting in stimulation of APCs and enhanced CD8+ T-cell infiltration. The present study evaluates STING agonists, alone...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zaidi, Ali H., Kelly, Ronan J., Gorbunova, Anastasia, Omstead, Ashten N., Salvitti, Madison S., Zheng, Ping, Kosovec, Juliann E., Lee, Soyoung, Ayazi, Shahin, Babar, Laila, Finley, Gene G., Goel, Ajay, Jobe, Blair A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2021
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7899550/ https://www.ncbi.nlm.nih.gov/pubmed/33659041 http://dx.doi.org/10.18632/oncotarget.27886

Ejemplares similares

Prognostic immune markers for recurrence and survival in locally advanced esophageal adenocarcinoma
por: Babar, Laila, et al.
Publicado: (2019)

Magnetic Sphincter Augmentation and Postoperative Dysphagia: Characterization, Clinical Risk Factors, and Management
por: Ayazi, Shahin, et al.
Publicado: (2019)

High yield reproducible rat model recapitulating human Barrett’s carcinogenesis
por: Matsui, Daisuke, et al.
Publicado: (2017)

Prognostic and predictive biomarkers for response to neoadjuvant chemoradiation in esophageal adenocarcinoma
por: Matani, Hirsch, et al.
Publicado: (2022)

Primary tumor microRNA signature predicts recurrence and survival in patients with locally advanced esophageal adenocarcinoma
por: Matsui, Daisuke, et al.
Publicado: (2016)

CDK4/6 dual inhibitor abemaciclib demonstrates compelling preclinical activity against esophageal adenocarcinoma: a novel therapeutic option for a deadly disease
por: Kosovec, Juliann E., et al.
Publicado: (2017)

Magnetic sphincter augmentation (MSA) in patients with hiatal hernia: clinical outcome and patterns of recurrence
por: Ayazi, Shahin, et al.
Publicado: (2019)

Measurement of outflow resistance imposed by magnetic sphincter augmentation: defining normal values and clinical implication
por: Ayazi, Shahin, et al.
Publicado: (2020)

Liposomal Delivery of MIW815 (ADU-S100) for Potentiated STING Activation
por: Ji, Nan, et al.
Publicado: (2023)

The Potential Clinical Utility of Circulating Tumor DNA in Esophageal Adenocarcinoma: From Early Detection to Therapy
por: Kosovec, Juliann E., et al.
Publicado: (2018)

Comparison of surgical payer costs and implication on the healthcare expenses between laparoscopic magnetic sphincter augmentation (MSA) and laparoscopic Nissen fundoplication (LNF) in a large healthcare system
por: Ayazi, Shahin, et al.
Publicado: (2019)

Combination of Interleukin-15 With a STING Agonist, ADU-S100 Analog: A Potential Immunotherapy for Prostate Cancer
por: Esteves, Ana M., et al.
Publicado: (2021)

The influence of accessory dwelling unit (ADU) policy on the contributing factors to ADU development: an assessment of the city of Los Angeles
por: Kim, Dohyung, et al.
Publicado: (2023)

Tumor Microenvironment before and after Chemoradiation in Locally Advanced Rectal Cancer: Beyond PD-L1
por: Tayshetye, Pritam, et al.
Publicado: (2022)

Cyto-IL-15 synergizes with the STING agonist ADU-S100 to eliminate prostate tumors and confer durable immunity in mouse models
por: Papaevangelou, Efthymia, et al.
Publicado: (2023)

ADuLT: An efficient and robust time-to-event GWAS
por: Pedersen, Emil M., et al.
Publicado: (2023)

Establishing Magnetic Resonance Imaging as an Accurate and Reliable Tool to Diagnose and Monitor Esophageal Cancer in a Rat Model
por: Kosovec, Juliann E., et al.
Publicado: (2014)

Chevalier Jackson: father of endoscopic surgery, and champion of women in medicine, social justice, and public health
por: Eriksson, Sven E., et al.
Publicado: (2023)

The Utility of Symptom Association Probability (SAP) in Predicting Outcome After Laparoscopic Fundoplication in Patients with Abnormal Esophageal Acid Exposure
por: Vaiciunaite, Donata, et al.
Publicado: (2023)

COVID-19 outbreak and surgical practice: The rationale for suspending non-urgent surgeries and role of testing modalities
por: Grubic, Andrew D, et al.
Publicado: (2020)

Pneumothorax as the presenting manifestation of COVID-19
por: Ayazi, Shahin, et al.
Publicado: (2020)

COVID-19 outbreak and endoscopy: Considerations in patients encountered in a foregut surgery practice
por: Olszewski, Tanya, et al.
Publicado: (2020)

Gastric remnant mesentero-axial volvulus following Roux-en-Y esophagojejunostomy: A rare complication
por: Grubic, Andrew D., et al.
Publicado: (2021)

Blocking Tim-3 enhances the anti-tumor immunity of STING agonist ADU-S100 by unleashing CD4(+) T cells through regulating type 2 conventional dendritic cells
por: Luo, Jing, et al.
Publicado: (2023)

Esophageal retention cyst: Esophagogastric junction outflow obstruction (EGJOO) as a potential etiology and management with endoscopic mucosal resection (EMR)
por: Mehta, Nisarg, et al.
Publicado: (2022)

Intratumoral injection of STING ligand promotes abscopal effect
por: Baird, Jason R, et al.
Publicado: (2014)

Acquired Morgagni hernia following coronary artery bypass graft (CABG) with successful robotic repair of hernia
por: Tamesis, Steven A., et al.
Publicado: (2022)

Acute superior mesenteric artery syndrome with complete foregut obstruction following Nissen fundoplication
por: Vaiciunaite, Donata, et al.
Publicado: (2023)

Intratumoral administration of STING-activating nanovaccine enhances T cell immunotherapy
por: Jiang, Xiaoyi, et al.
Publicado: (2022)

Removal of the magnetic sphincter augmentation device: an assessment of etiology, clinical presentation, and management
por: Eriksson, Sven, et al.
Publicado: (2023)

The impact of delayed gastric emptying as measured by gastric emptying scintigraphy on the outcome of magnetic sphincter augmentation
por: Eriksson, Sven E., et al.
Publicado: (2023)

Intratumoral Delivery of STING Agonist Results in Clinical Responses in Canine Glioblastoma
por: Boudreau, C. Elizabeth, et al.
Publicado: (2021)

Correction: Intratumoral administration of STING-activating nanovaccine enhances T cell immunotherapy
Publicado: (2022)

Ross for Valve replacement In AduLts (REVIVAL) pilot trial: rationale and design of a randomised controlled trial
por: Whitlock, Richard, et al.
Publicado: (2021)

Prognostic Value and Targeted Inhibition of Survivin Expression in Esophageal Adenocarcinoma and Cancer-Adjacent Squamous Epithelium
por: Malhotra, Usha, et al.
Publicado: (2013)

Multifactorial dysphagia: Azygos vein aneurysm (AVA) and esophagogastric junction outflow obstruction (EGJOO)
por: Morton, Scott, et al.
Publicado: (2021)

Tu1667: HIATAL HERNIAS AND ABDOMINAL WALL HERNIAS: PREDICTORS OF ASSOCIATION IN A LARGE COHORT OF PATIENTS
por: Mehta, Nisarg, et al.
Publicado: (2022)

Predictors of favorable outcome after pyloroplasty for gastroparesis: should response to pyloric dilation or Botox injection be used as a marker of surgical outcome?
por: Eriksson, Sven E., et al.
Publicado: (2023)

CD47 blockade enhances the efficacy of intratumoral STING-targeting therapy by activating phagocytes
por: Kosaka, Akemi, et al.
Publicado: (2021)

GERD after Peroral Endoscopic Myotomy: Assessment of Incidence and Predisposing Factors
por: Rassoul Abu-Nuwar, Mohamad, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_osr3todij45vrqla93qdlc3pf7