Identification of critical chemical modifications by size exclusion chromatography of stressed antibody-target complexes with competitive binding

Chemical modifications (attributes) in the binding regions of stressed therapeutic proteins may affect binding to target and efficacy of therapeutic proteins. The method presented here describes the criticality assessment of therapeutic antibody modifications by size-exclusion chromatography (SEC) o...

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Detalles Bibliográficos
Autores principales: Shi, Rachel Liuqing, Xiao, Gang, Dillon, Thomas M., McAuley, Arnold, Ricci, Margaret S., Bondarenko, Pavel V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7899689/
https://www.ncbi.nlm.nih.gov/pubmed/33616001
http://dx.doi.org/10.1080/19420862.2021.1887612

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7899689/
https://www.ncbi.nlm.nih.gov/pubmed/33616001
http://dx.doi.org/10.1080/19420862.2021.1887612

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